Macport remove inactive ports

You can use this to remove inactive ports:
sudo port uninstall inactive

You will gain additional space by removing downloaded distfiles with:
sudo port clean --all installed

But there is no way to find orphaned ports, as MacPorts does not track
if ports are installed as dependency or by request. But there is the
tool port_cutleaves which allows to remove possible no longer needed ports.

sudo port install port_cutleaves
sudo port_cutleaves

sudo port selfupdate

sudo port -u upgrade --enforce-variants outdated +universal